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Filtered Search Results
Medchemexpress LLC STF-31 | 724741-75-7 | 99.79% | 423.53 | 25 MG
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STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1) with an IC50 of 1 μM. It also functions as a NAMPT inhibitor, inhibiting glucose uptake in renal cell carcinoma (RCC) 4 cells.
- Selective inhibitor of glucose transporter 1 (GLUT1)
- Functions as a NAMPT inhibitor
- Inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells
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Selleck Chemical LLC Propidium Iodide
Propidium iodide (PI) is a red-fluorescent DNA stain which penetrates only damaged cellular membranes Propidium iodide (PI) is described for use in the determination of cell viability in cell suspension
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TARGETMOL CHEMICALS INC Azosemide 200MG
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Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Azosemide is a potent NKCC1 inhibitor (IC50s 0.246 µM and 0.197 µM for hNKCC1A and NKCC1B). Purity 98.93%
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eMolecules 2-TRIFLUOROMETHYL-3-ETHOX 5G
5000168980 2-TRIFLUOROMETHYL-3-ETHOX 5G
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Apexbio Technology LLC ML 281 200mg
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ML 281 (CAS 1404437-62-2) is a small-molecule inhibitor targeting serine/threonine kinase STK33 It is designed to block the phosphorylation activity of STK33 thereby interfering with downstream signaling pathways regulated by STK33-mediated phosphorylation events ML 281 exerts its biological activity primarily through selective inhibition of STK33 kinase activity In biochemical assays ML 281 demonstrates potent inhibitory effects with an IC50 value of approximately 14 nM against STK33 Based on these pharmacological properties ML 281 holds research potential in investigating the biological role of STK33 in tumor cell survival cellular proliferation and oncogenic signal transduction pathways
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Medchemexpress LLC Sulfo-SPDB-DM4 | 1626359-59-8 | 99.8% | 1075.66 | C46H63ClN4O17S3 | 5 MG
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sulfo-SPDB-DM4 is a drug-linker conjugate for antibody-drug conjugate (ADC) research that delivers the maytansine-derived cytotoxin DM4 via a cleavable sulfo-SPDB linker. DM4 is an antitubulin maytansinoid that inhibits tubulin polymerization, causing mitotic arrest and apoptotic cell death. The product is supplied as a solid for use in ADC development and related in vitro studies.
- Delivers DM4, a maytansine-derived antitubulin payload, for ADC payload evaluation.
- Cleavable sulfo-SPDB linker enables intracellular release of the cytotoxin.
- High purity (≈99.8%) suitable for research applications.
- Supplied as a solid, white to yellow, shipped on dry ice.
- Soluble in DMSO at 50 MG/ML with ultrasonic assistance; hygroscopic DMSO affects solubility.
- Recommended storage at -80°C, protected from light, under nitrogen.
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Medchemexpress LLC DC-BPi-03 | 2758411-46-8 | C14H14N4O2S | 25 MG
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DC-BPi-03 is a potent BPTF-BRD inhibitor with an IC50 of 698.3 nM and a Kd of 2.81 μM. It is intended for research use only and is not for sale to patients.
- Potent BPTF-BRD inhibitor
- Inhibits BPTF-BRD with an IC50 of 698.3 nM
- Inhibits BPTF-BRD with a Kd of 2.81 μM
- For research use only
- Relevant to cancer research
- Relevant to blood or cardio-cerebrovascular disease research
- Relevant to blood disease research
- Relevant to leukemia/lymphoma/myeloma research
- Relevant to cancer targeted therapy
- Relevant to cancer metabolism and metastasis
- Acts as an epigenetic reader domain inhibitor
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Medchemexpress LLC Fmf-06-098-1 | 2769753-07-1 | 98.8% | 1073.76 | 25 MG
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FMF-06-098-1 is a multi-target kinase PROTAC degrader that targets degradation kinases such as AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1. The compound is composed of a target protein ligand, a VHL ligand, and a linker.
- Store powder at -20°C for 3 years, or 4°C for 2 years.
- Store in solvent at -80°C for 6 months, or -20°C for 1 month.
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eMolecules 2-FLUORO-5-4 4 5 5-TETRAME 1G
5000211082 2-FLUORO-5-4 4 5 5-TETRAME 1G
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eMolecules 2-FLUORO-5-4 4 5 5-TETRAME 5G
5000211083 2-FLUORO-5-4 4 5 5-TETRAME 5G
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eMolecules 2-QUINOLINECARBOXALDEHYDE 25G
5000165293 2-QUINOLINECARBOXALDEHYDE 25G
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TARGETMOL CHEMICALS INC 8-Prenylnaringenin 1MG
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Also available in 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. 8-Prenylnaringenin is a phytoestrogen with high estrogenic activity, Purity 99.67%
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Medchemexpress LLC 5-Amino-8-hydroxyquinoline | 13207-66-4 | 160.18 | 100 MG
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5-Amino-8-hydroxyquinoline (5A8HQ; 5AHQ) is an orally active, non-competitive 20S proteasome inhibitor. It has the ability to inhibit NF-κB activity and induce the death of cancer cells, while exhibiting low cytotoxicity towards normal hematopoietic cells. This compound can be utilized for research related to cancer, particularly leukemia.
- Orally active.
- Functions as a non-competitive 20S proteasome inhibitor.
- Inhibits NF-κB activity.
- Induces cancer cell death.
- Shows low cytotoxicity towards normal hematopoietic cells.
- Can be used for cancer research, including leukemia.
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Medchemexpress LLC Almonertinib mesylate | 2134096-06-1 | 99.7% | 621.75 | 25 MG
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Almonertinib mesylate (HS-10296 mesylate) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. It shows great inhibitory activity against T790M, T790M/L858R, and T790M/Del19 (IC50: 0.37, 0.29, and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). It is used for the research of non-small cell lung cancer, and can also inhibit other EGFR sensitive mutations, including G719X, del19, L858R, and L861Q.
- Orally available
- Irreversible
- Third-generation EGFR tyrosine kinase inhibitor
- High selectivity for EGFR-sensitizing and T790M resistance mutations
- Great inhibitory activity against T790M, T790M/L858R and T790M/Del19
- Used for research of non-small cell lung cancer
- Inhibits EGFR sensitive mutations (G719X, del19, L858R, L861Q)
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Apexbio Technology LLC Dihydrexidine hydrochloride 158704-02-0 5mg
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Dihydrexidine hydrochloride is a small-molecule agonist targeting the dopamine D1 receptor It is designed to selectively activate the D1 receptor subtype thereby modulating cyclic AMP-mediated signal transduction pathways Dihydrexidine hydrochloride exerts its biological activity primarily through dopaminergic D1 receptor stimulation It demonstrates receptor activation with an EC50 value of approximately 72 21 nM Based on these pharmacological properties dihydrexidine hydrochloride holds research potential in investigating dopaminergic neurotransmission mechanisms and evaluating dopamine receptor involvement in neural function as well as in biological screening assays for receptor-mediated functional effects in neuronal models
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